![]() 6 More studies need to be conducted, particularly in humans, to further the understanding of specific agents or conditions that enhance the role of the musculoskeletal ECM in mechanotransduction and force transmission and in the RBE (ie, the protective effect that a novel exercise bout has on subsequent exercise sessions). This protective effect occurred against different types of the second EIMD. In a rat model, RBE was shown to occur as early as 2 days after the first bout of contractions of the dorsiflexor muscles in the left hind limbs, and it persisted for several weeks. ![]() 4, 6, 7 For example, compared with a novel bout of eccentric exercise that causes muscle damage and loss of strength, a subsequent bout of eccentric exercise, when performed days or even weeks later, is associated with less loss of contractile force, a decreased soreness, and a reduction in the amount of muscle proteins in the blood, the biomarkers of tissue disruption, when compared with the first bout of exercise. Hence, although high-force eccentric contractions are associated with EIMD and microtrauma or injury, they are also known to provide, paradoxically, significant protection against future injury through what is known as the repetitive bout effect (RBE). The resulting biochemical and molecular responses within both skeletal muscles and tendons promote adaptation to mechanical loading and physical activity. A substantial body of evidence has demonstrated that exercise leads to local enhancement of metabolic activity, circulatory responses, and collagen turnover, together with an elevated expression of growth factors, such as insulin growth factor 1 (IGF-1) and transforming growth factor β (TGF-β). It is well established that ECMs of both the muscles and tendons are sensitive to the mechanical stimuli and tension generated by muscular contractions, particularly by a lengthening or eccentric muscle action against resistance from either isotonic, isometric, or isokinetic modalities. 4, 5 This structural alteration of the skeletal muscle tissue is known to limit performance in repetitive activities due to a decreased range of motion, decreased force production, and pain. ![]() 2, 3 However, it is clear that shear stress and injury to other extramuscular elements of connective tissue (extracellular matrix proteins basal lamina types 1, 3, 4, and 6 collagen proteoglycan/glycosoaminoglycans epimysium/perimysium/endomysium and tendon)-are also involved. 1 Traditionally, DOMS has largely been explained by myogenic factors associated with structural alteration of the sarcolemmal membrane, damage to Z disks of sarcomeres and disruption of cytoskeletal proteins (ie, dystrophin, desmin, titin, integrins, and fibronectin). EIMD results in delayed-onset muscle soreness (DOMS) in association with an increased presence of muscle-specific proteins in the blood, muscle edema, and fiber swelling. *We do not use bovine (cow) as a source for our collagen.The use of mechanical stressors that overload skeletal muscle and associated connective tissue often result in some degree of exercise-induced muscular damage (EIMD). ![]() The exact methods are considered proprietary, and thus we cannot share it. The Liquid BioCell Collagen/HA Matrix is derived from chicken sternal cartilage, which undergoes a hydrolyzation process to lower its molecular weight to a precise range for optimal bioavailability. If the collagen that is extracted from the chicken is extracted in LIQUID form or if it is extracted in a dry form and then rehydrated to create 'liquid collagen'? QUESTIONS ASKED ABOUT OUR SOURCE/PROCESS OF THE COLLAGEN: The chickens are killed/processed for their meat and the farms then supply the chicken sternum to the BioCell company.Ī: While the exact composition fed to the chickens is confidential, it is intended to provide the proper health and nutrition to the chickens. Liquid BioCell® is GMO, antibiotic- and hormone-free. All Liquid BioCell® products contain the ingredient Liquid BioCell®, which is a matrix of collagen, hyaluronic acid and chondroitin a highly bioavailable liquid form of a patented sternal cartilage, which is derived from a by-product of humanely-treated chickens from the world’s most reputable and regulated farms located in the US and Europe.įor example, the US farms are not only inspected by the FDA and USDA, but there are full-time USDA inspectors on site at all times.
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